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RT NO BETTER THAN SORAFENIB FOR HCC

November 19, 2017

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SBRT FOR ELDERLY WITH NSCLC

Patients in their 80s and 90s who have early-stage lung cancer but cannot undergo an operation can be treated safely and effectively with stereotactic body radiation therapy (SBRT), according to research presented by Cassidy et al at the 2017 Multidisciplinary Thoracic Cancers Symposium ( Abstract 111 ). The advanced form of radiation therapy (RT) was well-tolerated among this relatively understudied elderly population, indicating that SBRT is a viable option for patients who may otherwise be offered no curative treatment. While the primary treatment for early-stage lung cancer is surgical removal of the tumor, some patients may not be able to tolerate surgery due to health status, advanced age, or other factors. For these patients, the best curative option is SBRT, a specialized type of external beam RT that uses advanced imaging techniques to deliver extremely targeted radiation to a tumor. This high degree of precision makes SBRT particularly effective at sparing surround...

DIABETES-PANCREATIC CANCER CONNECTION

Diabetes and pancreatic cancer affect the same organ, but they have more in common than just their location. People who have one of these conditions are also more likely to have the other one. About 30 million Americans have diabetes. Pancreatic cancer is diagnosed in nearly 54,000 people each year, and it's the third-leading cause of cancer-related death. Most people aren't diagnosed until their cancer has already spread and is harder to treat. Researchers have been looking at the link between diabetes and pancreatic cancer for many years. Now they're trying to use this connection to diagnose pancreatic cancer earlier, when treatment is more likely to improve survival. The Diabetes-Pancreatic Cancer Link Diabetes is both a risk for, and a warning sign of, pancreatic cancer. "The relationship goes both ways," says Lynn Matrisian, PhD, chief science officer of the Pancreatic Cancer Action Network. Researchers don't know exactly why, but people who have...

PCSK9 INHIBITOR EVERY 6 MONTHS?

Treatment with inclisiran (Alnylam Pharmaceuticals/the Medicines Company), which suppresses proprotein convertase subtilisin-kexin type 9 (PCSK9) synthesis in the liver, can dramatically lower levels of LDL cholesterol and may be suitable for injection every 6 months, suggests a phase 2 randomized trial [x] . Such a dosing schedule would distinguish the potential dyslipidemia agent from the more familiar antibody-based PCSK9 inhibitors alirocumab ( Praluent , Sanofi/Regeneron) and evolocumab ( Repatha , Amgen), which are injected every few weeks. The ORION-1 trial was presented here today at the American College of Cardiology (ACC) 2017 Scientific Sessions by Dr Kausik K Ray (Imperial College London, UK), who is also lead author on the trial's publication at about the sa...

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RT NO BETTER THAN SORAFENIB FOR HCC

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